Development and Evaluation of a Time-Resolved Near-Infrared Fluorescence Finite Element Model
نویسندگان
چکیده
In this work a generalization of the approach allowing time-domain (TD) excitation and fluorescence data to be generated using a finite element model (FEM) is introduced. This new functionality allows simulation of temporal pointspread functions (TPSF) for a heterogeneous scattering and absorbing media of arbitrary geometry. In the first part of this paper, the approach used to develop a computationally efficient model for solving the time-dependent diffusion equation for excitation and fluorescence data is presented. In the second part, a detailed theoretical evaluation of the method is given by comparing the developed FEM simulations with analytical and Monte Carlo data. The total fluence (intensity data), shows qualitative match whereas meantime of flight is almost identical among the three models for both excitation and emission data. The results show that the model is reliable and warrants its use for future TD applications where diffusion modelling can be used.
منابع مشابه
Modeling Time Resolved Light Propagation Inside a Realistic Human Head Model
Background: Near infrared spectroscopy imaging is one of the new techniques used for investigating structural and functionality of different body tissues. This is done by injecting light into the medium and measuring the photon intensity at the surface of the tissue.Method: In this paper the different medical applications, various imaging and simulation techniques of NIRS imaging is described. ...
متن کاملQuantitative Comparison of Analytical solution and Finite Element Method for investigation of Near-Infrared Light Propagation in Brain Tissue Model
Introduction: Functional Near-Infrared Spectroscopy (fNIRS) is an imaging method in which light source and detector are installed on the head; consequently, re-emission of light from human skin contains information about cerebral hemodynamic alteration. The spatial probability distribution profile of photons penetrating tissue at a source spot, scattering into the tissue, and being released at ...
متن کاملSolution of Wave Equations Near Seawalls by Finite Element Method
A 2D finite element model for the solution of wave equations is developed. The fluid is considered as incompressible and irrotational. This is a difficult mathematical problem to solve numerically as well as analytically because the condition of the dynamic boundary (Bernoulli’s equation) on the free surface is not fixed and varies with time. The finite element technique is applied to solve non...
متن کاملEvaluation of Reflection Optical Imaging Characteristics Using Fluorescence with Near Infrared Wavelength at Different Depths of Tissue Equivalent Phantom
متن کامل
Modeling Time Resolved Light Propagation Inside a Realistic Human Head Model
BACKGROUND Near infrared spectroscopy imaging is one of the new techniques used for investigating structural and functionality of different body tissues. This is done by injecting light into the medium and measuring the photon intensity at the surface of the tissue. METHODS In this paper the different medical applications, various imaging and simulation techniques of NIRS imaging is described...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011